CALCA and infection: In addition, despite the reports that SARS-CoV-2 with the D614G spike protein mutation had a higher infectivity than that with WT spike protein [30,31,32], KC effectively prevented both pseudotyped SARS-CoV-2 infections at a concentration of 2 μM: 89.9% inhibition in WT and 69.7% inhibition in D614G.