For instance, ALS- and FTLD-associated TDP-43 mutations such as D169G, K263E, G298S, A315T, M337V, Q343R, G348C, N352S, and A382T are associated with the accelerated disease onset and enhanced TDP-43 aggregates in ALS [49,50]. This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.