TARDBP and Perry syndrome: In addition, it has become increasingly clear over the past decade that several other neurodegenerative diseases such as limbic-predominant age-related TDP-43 encephalopathy (LATE) and Perry’s syndrome share a common pathological feature characterized by the presence of aberrant phosphorylation, ubiquitination, cleavage, and/or nuclear depletion of TDP-43 in neurons and glial cells, known as ‘TDP-43 proteinopathies’ [12,13,14].