TARDBP and amyotrophic lateral sclerosis: In C. elegans (worm) and D. rerio (zebrafish) models expressing mutant TDP-43 (G348C), Vaccaro et al. showed that ER stress suppression with pharmacological compounds is neuroprotective against TDP-43 proteinopathy [129], and the ER stress is a promising therapeutic target with respect to therapeutic research for ALS and FTLD.