TARDBP and proteostasis deficiencies: Although the findings do not conclusively prove whether the aberrant TDP-43 protein is fundamentally involved in the pathophysiology of other neurodegenerative diseases, the expanded neurodegenerative spectrum of TDP-43 proteinopathy, including LATE and Perry’s syndrome with TDP-43-positive inclusions, suggests that TDP-43 may, at least in part, mediate neurodegeneration.