TARDBP and proteostasis deficiencies: Limbic-predominant age-related TDP-43 encephalopathy (LATE) is clinically associated with an amnestic dementia syndrome that mimics Alzheimer’s-type dementia, and its neuropathological change is defined by a stereotypical TDP-43 proteinopathy in older adults, with or without co-existing hippocampal sclerosis pathology.