TARDBP and amyotrophic lateral sclerosis: Overexpression of WT or ALS-associated mutant TDP-43 (M337V, Q331K, A382T, G348C) interrupts the ER-mitochondria interaction, while TDP-43 is also associated with the activation of glycogen synthase kinase-3 (GSK-3) and disturbs Ca2+ homeostasis [128].