Due to the limited expression of DC-SIGN in hepatocytes, the infection occurs via the DC-SIGN homologue liver/lymph node-specific intercellular adhesion molecule-3-grabbing non-integrin (L-SIGN), which is present in liver sinusoidal epithelial cells, heparan sulfate mediation, or the scavenger receptor class A member I (SCARA-I), that also has been shown to play a role in the uptake of adenovirus 5 and herpes simplex virus [11,13,15,16,17]. This evidence concerns the gene CD209 and infection.