Another inverse correlation was reported for Bcl-xL in AML, CML and DLBCL cells, where S63845 resistance correlated with high Bcl-xL expression, suggesting that in these cells, Bcl-xL may functionally compensate for the inhibition of Mcl-1 [24,38]. The gene discussed is BCL2L1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.