PARP1 and neoplasm: 18F-PARPi targeting poly [ADP-ribose] polymerase 1 (PARP-1) expression in DIPG, 11C-Choline assessing choline kinase regulation, and 18F-fluoro-3′-deoxy-3’-L-fluorothymidine (18F-FLT) PET, which allows in vivo assessment of tumor proliferation, have shown mitigated results and did not translate into clinical practice [17,18].