Systemic lupus erythematosus: The 28 DEGs involved in this pathway are C7, CTSG, ELANE, GRIN2B, HIST1H2AD, HIST1H2AH, HIST1H2AJ, HIST1H2AM, HIST1H2BE, HIST1H2BF, HIST1H2BI, HIST1H2BL, HIST1H2BO, HIST1H3D, HIST1H3F, HIST1H3I, HIST1H3J, HIST1H4A, HIST1H4B, HIST1H4C, HIST1H4D, HIST1H4E, HIST1H4L, HIST2H2AB, HIST2H2AC, HIST2H2BF, HIST2H3D, and HIST3H2BB. The gene discussed is H2AC21; the disease is systemic lupus erythematosus.