METAP2 and colorectal carcinoma: For instance, higher expression levels of CUPsig were associated with increased resistance of CRC cell lines to Flavopiridol, MetAP2 Inhibitor, LDN-193189, and Phenformin; however, it resulted in increased sensitivity of cell lines to TANK_1366, PARP_9482, XAV939, Cisplatin, PARP_9495, PI-103, Bleomycin (50 μM), Bleomycin (10 μM), and A-770041 (Figure 6D).