CTSB and colorectal carcinoma: CTSB, TIMP2, ARL4C, UNC5B, TGFB1I1, and HOPX, NCOA5, and AGMAT have been recorded in the DisGeNET database (https://www.disgenet.org/ (accessed on 11 November 2021)) as CRC known disease genes (Supplementary Table S5).