Hepatic factors that alleviate the metabolic dysfunction upon hepatic steatosis include ANGPTL4, ANGPTL6, FGF21, IGF-1, etc. These proteins regulate adipocyte activation to increase energy expenditure, increase insulin sensitivity and glucose uptake by the body, reduce plasma triglyceride levels, and regulate cholesterol homeostasis. This evidence concerns the gene ANGPTL4 and Hepatic steatosis.