Hepatic factors that alleviate the metabolic dysfunction upon hepatic steatosis include ANGPTL4, ANGPTL6, FGF21, IGF-1, etc. These proteins regulate adipocyte activation to increase energy expenditure, increase insulin sensitivity and glucose uptake by the body, reduce plasma triglyceride levels, and regulate cholesterol homeostasis. The gene discussed is FGF21; the disease is Hepatic steatosis.