SNORD13 and Huntington disease: Irrespective of the mechanism(s) possibly linking mHTT to SNORD13 and the source of this snoRNA (currently unknown), we can speculate that the increase in the plasma level of SNORD13 in patients with HD may peripherally report a ‘tipping point’ in the pathogenic cascade at the neuronal level, while normal levels may mark a ‘molecular pre-manifest status’ in disease evolution.