Moreover, the PP2A regulatory subunit PPP2R5E has been identified as a direct target of miR-19b [26], and PP2A inhibition has been reported to determine 5-FU resistance in CRC cells, being PPP2R5E downregulation one of the contributing molecular alterations described to inhibit PP2A in this disease [42]. The gene discussed is PPP2R5E; the disease is colorectal carcinoma.