Relative to normal human tissues, ASPH is overexpressed in a wide variety of malignant tumors affecting the pancreas, breast, prostate, cervix, ovary, fallopian tube, larynx, lung, thyroid, gall bladder, kidney, bladder, brain, gastrointestinal tract (esophagus, stomach and colon) and liver (cholangiocellular carcinoma, HCC) and includes malignancies that commonly affect children (i.e., glioblastoma and Wilms’ tumor) [3,5]. This evidence concerns the gene ASPH and cholangiocarcinoma.