Lastly, they showed that ELX/TEZ/IVA, via the rescue of CFTR activity, corrected K+ efflux, normalized intracellular Ca2+, and reduced P2 × 7R expression of CF monocytes with subsequent decreased NLRP3 expression, caspase-1 activation, and IL-1β secretion upon stimulation with LPS and ATP; moreover, the HEMT normalized plasma eATP and IL-1β levels of treated individuals [145,146]. Here, NLRP3 is linked to cystic fibrosis.