The subsequent study conducted by Zhang and colleagues confirmed these findings since the combination of LUM/IVA not only was unable to improve phagocytosis of F508del/F508del MDMs but even worsened it; in fact, CF MDMs on LUM/IVA had decreased B. cenocepacia phagocytosis compared to CF MDMs not on CFTR modulators and non-CF MDMs [132]. Here, CFTR is linked to cystic fibrosis.