CFTR and cystic fibrosis: In fact, in the study of Shrestha and colleagues, these CFTR-associated modulators were able to improve the capability of (R)-roscovitine (seliciclib), a synthetic, low molecular weight, tri-substituted purine, to enhance the bacterial-killing function of MDMs infected with CF clinical isolates of B. cenocepacia and P. aeruginosa [142].