In their study, the authors showed that Piezo1 gene deletion in the myeloid lineage of genetically engineered mice prevented the development of renal fibrosis by decreasing macrophage recruitment to the injured kidney, most likely by regulating CCL2–CCR2 signaling via Notch activity, and by restraining macrophage activation and secretion of pro-inflammatory cytokines (IL-1β, TNF-α, IL-6) via a calpain-dependent signaling pathway (Figure 4). This evidence concerns the gene CCL2 and renal fibrosis.