In summary, there is increasing evidence that VTN exhibits more capacity for regulating neural function than previously thought, and future studies should focus on: (1) the mechanisms of VTN in neurodegenerative diseases; (2) the expression of VTN in the aging process and its effect on neurons; (3) investigating whether VTN-related drugs can ameliorate neuronal damage; (4) how to open the BBB through VTN to deliver drugs. The gene discussed is VTN; the disease is neurodegenerative disease.