A study highlighted NEDD4 as an invasion-associated molecule in gallbladder carcinoma and demonstrated that at the transcriptional level NEDD4L regulates MMP-1 (Matrix metalloproteinase-1) and MMP-13 expression, which is overexpressed at an early stage of tumor invasion in various malignant tumors [156]. The gene discussed is NEDD4L; the disease is neoplasm.