INS and hepatocellular carcinoma: In a study conducted in 2016, Calo et al. reported that miR-21, an oncomiRNA overexpressed in HCC and other liver etiologies characterized by the presence of steatosis, promotes hepatic insulin resistance and lipogenesis in obesogenic-diet-fed mice through a fine regulation of Foxo1, Insig2, STAT3, and HNF4-α.