Furthermore, the research group demonstrated that inhibition of HULC expression was associated with improved pathological state and liver-function-related indexes of hepatic lipid deposition, improved degree of hepatic fibrosis, reduced hepatocyte apoptosis but, also, the inhibition of MAPK signaling pathway, evidence that all supports a clear association between increased HULC expression and NAFLD progression [225]. This evidence concerns the gene HULC and metabolic dysfunction-associated steatotic liver disease.