MT-CYB and colorectal carcinoma: The results showed that the transcription levels of 12S rRNA, 16S rRNA, ND1, Cytb, ND6, and TFAM were significantly upregulated with MTERF1 overexpression and significantly downregulated with MTERF1 knockdown while the transcription level of NDUFB8 remained unchanged with both MTERF1-overexpressing and MTERF1-knockdown CRC cells (Figure 4B).