Expression changes in UPS genes identified in both ST_EPN_RELA and PF_EPN_B included several differentially expressed UPS genes associated with interferon gamma signaling (MID1, PIAS1, TRIM2, TRIM22, TRIM45) that may promote a proinflammatory milieu similar to that observed upon viral infections (Table 4). This evidence concerns the gene PIAS1 and viral infectious disease.