In addition, in supratentorial (ST) EPN, NOTCH1 expression was associated with cancer stem cell (CSC) markers, VEGFA and L1CAM, and the ST_EPN_RELA subtype showed the activation of selected key members of the Notch signaling pathway (NOTCH1, JAG1, JAG2, HES4) [22]. The gene discussed is L1CAM; the disease is cancer.