Accumulating studies have revealed that CD90+ HCC cells exhibited self-renewal, pro-tumorigenicity and aggressive phenotypes [30] with the activation of AKT/EphA2 signaling [31], IL-6/JAK2 signaling [32], AKT and mTOR signaling [33] as well as MAP3K8 signaling [34]. This evidence concerns the gene MTOR and hepatocellular carcinoma.