It has been reported that the cancer autocrine molecule C-X-C motif chemokine 11 (CXCL11), accumulated in the TME, could increase the expression of stemness-related genes and maintain the stem cell features of α2δ1+ liver CSCs through chemokine (C-X-C motif) receptor 3 (CXCR3)/ERK1/2 signaling [106]. Here, CXCR3 is linked to cancer.