PAX5 and obesity due to melanocortin 4 receptor deficiency: Notably, Melka et al. showed that three previously identified loci of obesity (rs16933812 on Paired box protein Pax-5 [PAX5], rs7638110 on Mitochondrial Ribosomal Protein S22 [MRPS22], and rs9930333 on Fat Mass and Obesity-associated [FTO]) were also associated with elevated systolic blood pressure in an adolescent Canadian population [40].