Moreover, the importance of Cat S and PPARγ in the development of PH-associated SLE was proven by experiments using a selective inhibitor of Cat S (Millipore-219393), which upregulated PPARγ and suppressed Cat S expression to prevent pulmonary arterial remodeling and right ventricular hypertrophy in experimental SLE. Here, PPARG is linked to systemic lupus erythematosus.