To demonstrate this possible correlation between CHK2 and BQ in vivo, we examined through immunohistochemistry the expression of active CHK2 (p-CHK2 Thr68; hereafter referred to as p-CHK2) in primary breast tumour tissues (Figure 7A) in the tissue microarray (TMA), correlating this with nuclear BQ expression. This evidence concerns the gene CHEK2 and breast neoplasm.