Inflammasomes are multiprotein complexes that contain (i) a sensor protein, such as NLRP1 (NLR (NOD-like receptor) family pyrin domain containing 1), NLRP3, NLRC4 (NLR family CARD (caspase activation recruitment domain) domain containing 4), AIM2 (absent in melanoma 2), or pyrin, which names the corresponding type of inflammasome; (ii) the adaptor protein ASC (apoptosis-associated speck-like protein containing a CARD); and (iii) the effector protein pro-caspase-1 (Figure 1). This evidence concerns the gene NLRP3 and melanoma.