C-reactive protein (CRP) levels in patients with psoriasis were significantly higher than controls (0.4 ± 0.4 mg/dL vs. 0.2 ± 0.2 mg/dL)(p = 0.02). Moreover, erythrocyte sedimentation rate (ESR) levels were also higher in patients with psoriasis than in controls (15.2 ± 9.5 mm/h vs. 8.8 ± 3.0 mm/h) (p = 0.004). This evidence concerns the gene CRP and psoriasis.