Furthermore, psoriasis and SCC are skin diseases both characterized by keratinocyte dysregulation with overexpression of NGAL and transcription factor 7-like 1 (Tcf7l1), its regulator, as reported by Xu et al. [48] Their in vitro study on human foreskin keratinocytes (HFK) demonstrated that NGAL expression increased with the Tcf7l1 level in HFKs undergoing differentiation and decreased significantly upon Tcf7l1 depletion. Here, LCN2 is linked to psoriasis.