Resveratrol targets viral infection regulation by modulating the activity of SIRTs (SIRT1, 2, 3, 5), particularly via SIRT1, protein kinase C, activator protein 1, 5′ AMP-activated protein kinase (AMPK), nuclear factor kappa β (NF-kβ), p53, early growth regulator 1 (EGR-1), sterol regulatory element-binding protein 1 (SREBP-1) and DNMT1 [142]. This evidence concerns the gene NFKB1 and viral infectious disease.