KDM5C and Intellectual disability: Like KDM6A, KDM5C is also an important chromatin remodeler controlling transcriptional programs within neurons to impact their differentiation, neuritic growth and synaptic activity [158,159,160,161,162], with KDM5C mutations leading to Claes-Jensen X-linked intellectual disability [163,164,165], although further studies including sex as a critical variable are needed.