In this research, we comprehensively carry out the experimental validation with 90 male rats to explore the individual induction of BPA and BPAF for prostatic hyperplasia, and the expression of the significant indexes of the NF-κB signaling pathway containing NF-κB p65, COX-2, tumor necrosis factor-α (TNF-α) and EGFR. This evidence concerns the gene EGFR and benign prostatic hyperplasia.