A subgroup analysis of sex according to obesity status showed that in the dominant model, the associations between LEP polymorphisms and leptin levels were significant only among obese women (rs2167270, 33.25 ± 27.83, p = 0.025; rs7799039, 33.23 ± 26.85, p = 0.008; Table 4). The gene discussed is LEP; the disease is obesity due to melanocortin 4 receptor deficiency.