In contrast, in HCC cells containing WT p53 (e.g., SK-Hep1, HepG2 cells), the DNA methyltransferase inhibitor 5-azacytidine relieves the transcriptional repression of LOXL4, and the accumulated LOXL4 can reactivate p53 and induce tumor cell apoptosis [95]. The gene discussed is TP53; the disease is hepatocellular carcinoma.