LOXL2 and hepatocellular carcinoma: Increased stromal stiffness can upregulate LOXL2 expression and secretion in HCC cells by activating the ITG-β1/α5/JNK/c-JUN pathway, which subsequently promotes fibronectin (FN) production, MMP-9 and CXCL12 expression, and BMDCs’ recruitment [72].