LOX and neoplasm: At present, it is believed that the LOX family is involved in tumorigenesis and progression mainly through intracellular and extracellular pathways: Intracellularly, some members of the LOX family can not only modify specific proteins to regulate the transcription of tumor-associated genes, but also rely on their non-catalytical active structural domains or catalytic by-products H2O2 to activate relevant signaling pathways [9,14]; Extracellularly, tumor-associated ECM is often accompanied by increased collagen deposition.