LOXL2 and neoplasm: However, it has been suggested that LOXL2 may have a more prominent tumor-promoting effect in tumor cells: Hee et al. found that intracellular LOXL2 confers a greater invasive ability to tumor cells through the upregulation of SNAIL1-induced EMT compared with extracellular LOXL2-remodeling ECM [63].