HIF-1α-antisense strand 2 (HIF1A-AS2)/lncRNA (RP11-366L20.2)-miRNA-29c axis-mediated LOX overexpression may promote M2 macrophage polarization and immune evasion, thus enhancing the resistance of paclitaxel and fluorouracil in GC [47]. The gene discussed is HIF1A; the disease is gastric cancer.