This is actually consistent with the above-mentioned study that the downregulation of LOXL2 facilitates the formation of circulating tumor cell (CTC) clusters and enhances the metastatic ability of tumor cells, which indicates that LOX family expression in tumor tissues should have corresponding temporal and spatial differences; (2) Promote cell proliferation and inhibit apoptosis: LOXL3 is significantly upregulated in human melanoma, and patients with high LOXL3 expression frequently have a poor prognosis [88,89]. This evidence concerns the gene LOXL3 and melanoma.