LOXL2 and hepatocellular carcinoma: In addition, it has also been reported that deubiquitinase (DUB) zinc finger RANBP2-type containing 1 (ZRANB1) can upregulate the transcription of LOXL2 and promote the proliferation and migration of HCC cells by deubiquitination of specificity protein 1 (SP1) [74].