Furthermore, in breast and thyroid cancer cells, LOX interacts with the promoter of EMT transcription factor SNAIL2 to promote the transcription of SNAIL2, thereby increasing the secretion of tissue inhibitor of metalloproteinase 4 (TIMP-4) and enhancing the invasive and metastatic ability of tumors [33]. This evidence concerns the gene SNAI2 and thyroid gland carcinoma.