Similarly, BAPN combined with anti-PD-1 therapy also significantly delays the progression of pancreatic cancer, the combination therapy increases GrzmB CD8+ T cells and improves the ratio of CD8+ T to Treg cells, and cytokine detection in tumor supernatants shows an increased expression of Granzyme B, TNFα, and chemotactic cytokines RANTES [133]. Here, CD8A is linked to familial pancreatic carcinoma.