LOXL3 and neoplasm: Currently, the tumor-promoting mechanism of LOXL3 mainly can be divided into two points: (1) promote tumor invasion and metastasis: the interaction between LOXL3 and SNAIL in the perinuclear region prevents the SNAIL degradation and nuclear export, which inhibits the transcription of E-cadherin gene CDH1 and induces EMT [85].