PTK2 and neoplasm: Studies on the extracellular effect of LOXL2 have revealed that the MiR200/Zinc finger E-box-binding homeobox 1(ZEB1) induces LOXL2-mediated collagen stabilization and deposition in TME, which can activate the ITG-β1/FAK/Src pathway in lung cancer cells and promote tumor invasion and metastasis [76].