APP and Alzheimer disease: A single 1.76 Gy total-brain irradiation with a Co-60 source in a swine model of AD produced significantly lower levels of hyperphosphorylated Tau (typical of Tau tangles in AD) in the frontal cortex and hippocampus, and of amyloid precursor protein and GAP43 (a marker associated with neosynaptogenesis, neuroplasticity and axonal regeneration) in the cerebellum [91].