CALCA and scleroderma: There are observations of protective roles of CGRP, that may be due to its vasodilator activity, in wound healing [55] and scleroderma [55], but of pro-inflammatory pathways, in terms of a role in T cell switching involving the IL-17 pathway to regulate cutaneous immunity [56] of possible relevance to psoriasis, where CGRP levels have been reported to be elevated [57].