The suggested upstream regulators on RNA level: lysine-specific histone demethylase 1A (Kdm1a), alpha-N-acetylneuraminide alpha-2,8-sialyltransferase (St8sia1) and beta-1,4 N-acetylgalactosaminyltransferase 1 (B4galnt1) can also be linked to AD. This evidence concerns the gene ST8SIA1 and Alzheimer disease.