CD40LG and polycystic ovary syndrome: Previous research also demonstrated that testosterone treatment reduced IgG production by 59.0% and that of IgM by 61.3% compared with controls [12]; this further supports our data where a negative correlation between testosterone levels and C1r was observed in PCOS, but not in control women, suggesting testosterone-mediated inhibition of the classical pathway of complement activation in the normal/resting physiological condition in PCOS.