In a meta-analysis of patients with PD comparing the different variants in the GBA1 gene, it was found that carriers of the N370S variant (new nomenclature c.1226A > G; p.N409S) had a 3-fold risk for developing PD, whereas carriers of other GBA1 variants exhibited a 10–15-fold risk for developing PD compared to the general population [5]. This evidence concerns the gene GBA1 and Parkinson disease.