The expression of the TEM8 mutant gene in ECs suppresses β1 integrin (ITGB1) activity and represses the activation of NFAT (Nuclear factor of activated T cells) a transcription factor regulated by calcium influx, causing the decrease of VEGFR1 expression and the increase of VEGFR2 signaling and the proliferation of hemangioma ECs due to increased binding of VEGF to VEGFR2 [67,69,70]. This evidence concerns the gene KDR and hemangioma.