PTEN hamartoma tumor syndrome (PHTS) represents a spectrum that includes Cowden syndrome 1 (CWS1), Bannayan-Riley-Ruvalcaba syndrome (BRRS), PTEN-related Proteus syndrome (PS), and PTEN-related Proteus-like syndrome [6,46]. The gene discussed is PTEN; the disease is Bannayan-Riley-Ruvalcaba syndrome.