LDL receptor-related protein 6 (LRP6), a Wnt co-receptor [70], interferes with the interaction between HSF1 and glycogen synthase kinase 3β (GSK3β), a Ser/Thr protein kinase inactivated by phosphorylation, resulting in the inhibition of HSF-1 ubiquitylation under oxidative stress following myocardial ischemia–reperfusion by reducing apoptosis and promoting nucleus stabilization [71]. This evidence concerns the gene LRP6 and myocardial ischemia.