SIRT3 and cardiac hypertrophy: The transcription factor forkhead box protein O 1 (FoxO1) is related to cardiac hypertrophy, and SIRT3, activated by oxidative stress, can combine with FoxO1 to activate its deacetylation, promoting the expression of the downstream molecules Muscle-RING-finger-1 (MuRF1) and Muscle-Atrophy-F-box (MAFbx/atrogin-1, an E3 ubiquitin ligase), ultimately alleviating myocardial hypertrophy [91].