MDM2 and cardiomyopathy: The reversal of murine double minute 2 (MDM2), a p53-specific E3 ubiquitin ligase, and SIRT1 reduced the activity of the apoptosis factor p53 through SIRT1-mediated p53 deacetylation and MDM2-mediated p53 ubiquitination, which alleviated oxidative stress and cell apoptosis in the tissues and cells of a cardiomyopathy model induced by adriamycin [86].