The level of La ribonucleoprotein domain family member 7 (LARP7), a regulator of the DNA damage response linked to ROS, was found to be reduced in the heart under the conditions of HF; accumulated ROS promoted LARP7 ubiquitination and degradation, and reduced sirtuin1 (SIRT1) stability and deacetylase activity, ultimately impairing oxidative phosphorylation and cardiac function [102]. This evidence concerns the gene LARP7 and hydrops fetalis.