EDA and X-linked hypohidrotic ectodermal dysplasia: Pathogenic variants of the gene EDA cause X-linked hypohidrotic ectodermal dysplasia (XLHED), a hereditary disease characterized by defective development of ectodermal appendages and a symptomatic triad consisting of hypotrichosis, oligo- or anodontia, and hypo- or anhidrosis [5,6,7,8].