TFEB and alcohol dependence: Moreover, it was demonstrated in mice that the knockout of transcription factor EB (TFEB) that regulates Atg7 and Atg14 leads to the suppression of autophagy and the disruption of lipid homeostasis in the liver, resulting in the accumulation of cholesterol and triglycerides, as well as in the development of steatosis, and also in alcohol-related cases.