On the other hand, ACE-DD homozygous females exhibited greater decreases in PANSS depression factor compared to ACE-II homozygous and ACE-ID heterozygous females: −8.4 ± 2.8 vs. −6.6 ± 2.8, z = −2.53, p = 0.010, Cohen’s d = 0.64. The gene discussed is ACE; the disease is major depressive disorder.