Regarding neuroinflammatory processes, polymorphisms of BMAL1 and CLOCK were associated with higher risk for multiple sclerosis in a Slovenian study conducted on 900 patients and 1024 healthy controls [59]; the deletion of REV-ERBα favored pro-inflammatory cytokine expression mediated by Th17 cells, worsening experimental autoimmune encephalitis (EAE) and colitis [52]. Here, NR1D1 is linked to colitis.