NR1D1 and ulcerative colitis: In a genetic association study on human patients, polymorphisms of PER3 were linked to a higher susceptibility to suffer both ulcerative colitis and Chron’s disease [54]; in a later study on dextran sulfate sodium-induced colitis in mice, those deficient in REV-ERBα were indeed more prone to suffer more severe symptoms based on the inactivation provoked by REV-ERBα on the NLRP3 inflammasome pathway [55].