Interestingly, they showed in RRMS an upregulation of the C3 gene, which was also observed by Absinta et al. in the “astrocytes inflamed in MS” cell subset [76], which is associated with A1-type pro-inflammatory AS, as well as PFN1, which is involved in the morphology and motility of AS. The gene discussed is PFN1; the disease is myeloid sarcoma.