CDK4 and hepatocellular carcinoma: Strikingly, the KM curve revealed that 10 of the 12 genes associated with the p53 signaling pathway, namely CCNB1, CCNE1, CDK1, CDK2, CDK4, CHEK1, GTSE1, RRM2, SERPINE1, and SFN, led to better OS of HCC patients from the low-expression group compared with those from the high-expression group (Figure 3A).