In this study, we used xenotransplantation to investigate the involvement of WNK1–OSR1–PPP2R1A during tumor-induced angiogenesis, via [tert x p53−/−] to observe the markers of angiogenesis and cell proliferation during carcinogenesis, and through feeding [HBx,src,p53−/−,RPIA] transgenic fish with drugs to examine the WNK–OSR1 inhibitors combination therapy with oligo-fucoidan. Here, PPP2R1A is linked to neoplasm.