We also compared the migration behavior of Hep3B cells in WNK1 overexpression or knockdown in endothelial cells, and the results showed WNK1 overexpression in endothelial cells promoting hepatoma cell migration, while WNK1 knockdown in endothelial cells reduced the hepatoma cell migration (Figure 2b). The gene discussed is WNK1; the disease is hepatocellular carcinoma.