Because WNK1 can be inactivated by PPP2R1A, the diminished expressions of ppp2r1ba and ppp2r1bb at 3 dpi might be pathogenic in the time ahead, so these results suggest the vital roles of wnk1a, osr1b, ppp2r1ba, and ppp2r1bb in endothelial cells might be involved in tumor-induced angiogenesis, which stimulates hepatoma cell proliferation. Here, PPP2R1A is linked to hepatocellular carcinoma.