We examined the senescence phenotype by checking the senescence-associated β-galactosidase (SA-β-gal) accumulation and found the SA-β-gal accumulation is indeed increased in tert transgenic fish, and oligo-fucoidan can reduce the SA-β-gal accumulation in tert transgenic fish treated with WNK1–OSR1 inhibitors, thus further reducing cancer formation. The gene discussed is WNK1; the disease is cancer.