Because WNK1 activates OSR1/SPAK, if OSR1 or STK39 are involved in tumor-induced angiogenesis, they are supposed to be upregulated from 2 dpi to 3 dpi, so these results indicate that WNK1 and OSR1 in hepatoma cells are involved in tumor-induced angiogenesis. Here, OSR1 is linked to hepatocellular carcinoma.