Knockdown of WNK1 in HUVEC cells with two independent shRNAs targeting on WNK1 (shWNK1-1 and shWNK1-2) significantly decreased the migrated hepatoma cells (Figure 8f), WNK1 overexpression in HUVEC cells significantly increased the HepG2 migration (Figure 9). Here, WNK1 is linked to hepatocellular carcinoma.