Cholinergic changes occur in the early stages of the pathology, so the use of AChEI could have a beneficial and protective effect by stimulating the release and uptake of the nerve growth factor (NGF) dependent on acetylcholine, favoring anti-neurodegenerative processes in the CBF of AD patients, and stimulating upregulation of nAChRs in the CNS [239]. This evidence concerns the gene NGF and Alzheimer disease.