Another approach to increase ABCA1 activity is through CS-6253, a peptide derived from the carboxyl-terminal of ApoE that is capable of oligomerizing ABCA1, increasing its levels, reversing cognitive impairment associated with ApoE4, and reducing tau hyperphosphorylation and Aβ accumulation in hippocampal neurons [160]. Here, ABCA1 is linked to Cognitive impairment.