As indicated above, E2F4 can regulate more than 7000 genes involved in several activities key to AD progression, such as DNA repair, RNA processing, stress response, apoptosis, ubiquitination, protein transport and targeting, protein folding, and I-κB kinase/NF- κB cascade, according to studies performed in a lymphoblastoid cell line [27]. Here, E2F4 is linked to Alzheimer disease.