Epigenetic editing of the Dlg4/PSD95 gene promoter led to a local epigenetic reprogramming and increased PSD-95 expression, impacting various plasticity-associated processes, and importantly, restoring memory deficits in the AD mice model AβPPswe/PS-1 [91] (for more details on this topic see Scheme 1). The gene discussed is DLG4; the disease is Alzheimer disease.