NFKBIA and hypohidrotic ectodermal dysplasia: Mutations in these 16 genes (Table S1) have been reported to impede the normal development of ectodermal-derived structures [6,7], while mutations in three of these genes (i.e., NEMO/ inhibitor of nuclear factor kappa B kinase regulatory subunit γ (IKBKG), nuclear factor kappa B inhibitor α (NFKBIA), and inhibitor of nuclear factor kappa B kinase subunit β (IKBKB)) result in anhidrotic ectodermodysplasia with immunodeficiency (EDA-ID) [2].