One study concluded that PPARGC1A genotype Gly482Ser remains a strong candidate thrifty gene in the Pacific due to the association between Gly482Ser genotypes and BMI in Tongans and the worldwide frequency distribution of the Gly482Ser risk allele [17], while a separate study concluded that this gene should not be considered a candidate thrifty gene locus in Pacific populations, no statistically significant evidence of an association between Gly482Ser PPARGC1A and BMI, type 2 diabetes, or gout was discovered [18]. The gene discussed is PPARGC1A; the disease is type 2 diabetes mellitus.