PNPLA8 and myocardial ischemia: Similarly, the deletion of PNPLA8 in adult mouse cardiomyocytes is also protective from myocardial ischemia/reperfusion injury [118], although the global deletion of PNPLA8 in mice leads to various physiological defects, including growth retardation, kyphosis, muscle weakness, and glomerular injury [115,116,117].