LCLAT1 and amyotrophic lateral sclerosis: Intriguingly, the ablation of ALCAT1 activity in mice could either attenuate motor neuron dysfunction, inflammation, and muscle atrophy in a model of ALS [122], or inhibit MPTP-induced neurotoxicity, apoptosis, and motor deficits [40], indicating that ALCAT1 may be a therapeutic target for treating neuronal diseases.