VHL and renal carcinoma: VHL (a combination of CNS hemangioblastoma and renal or pancreatic cysts, pheochromocytoma, renal cancer, and ectodermal cystadenoma and other diseases) inactivation in the zebrafish stabilizes HIF-1α and EPAS1 with consequent upregulation of specific target genes involved in cell proliferation, angiogenesis, and erythropoiesis, increasing the ability of the blood to transport oxygen [32].